Promethazine HCl and Codeine Phosphate Oral Answer really should be employed with warning in patients with impairment of hepatic functionality, and patients should be monitored intently for respiratory depression, sedation, and hypotension.
Prior to having this medication, explain to your doctor or pharmacist For anyone who is allergic to promethazine or to dextromethorphan; or to almost every other phenothiazines (including prochlorperazine); or For those who have every other allergies.
A perhaps lethal symptom complex at times called Neuroleptic Malignant Syndrome (NMS) continues to be described in Affiliation with promethazine HCl by itself or together with antipsychotic medication.
The precise system of action of codeine and various opiates is just not recognised; nonetheless, codeine is believed to act centrally about the cough center. In abnormal doses, codeine will depress respiration.
Be certain you understand how to get this product and what other drugs you'll want to steer clear of taking with it. See also Drug Interactions portion. Get health-related help immediately if any of such very major side effects take place: sluggish/shallow breathing, abnormal lightheadedness, serious drowsiness/dizziness, trouble waking up.
Postmarketing situations of respiratory depression, which include fatalities, are already noted with usage of promethazine hydrochloride in pediatric clients below 2 a long time of age. A variety of pounds-primarily based doses of promethazine hydrochloride have resulted in respiratory depression in these clients.
Don't choose this medication for several times prior to allergy screening since exam results may be affected.
Clients must be encouraged to measure promethazine with codeine syrup using an correct measuring machine. A house teaspoon just isn't an correct measuring device and may lead to overdosage, particularly when a 50 percent a teaspoon is calculated.
Choose this medication by mouth with or with out food as directed by your doctor, commonly each and every 4 to six hrs as necessary. Considering the fact that dosing tips could range, carefully stick to your health practitioner's Instructions for using this medication.
A family teaspoon will not be an precise measuring device and could lead on to overdosage, especially when fifty percent a teaspoon is to be measured. It really is strongly proposed that an exact measuring device be applied. A pharmacist can offer an appropriate system and can provide Recommendations for measuring the proper dose.
It is soluble in h2o and freely soluble in Alcoholic beverages. The molecular fat is 320.88. Its molecular formula is C17H20N2S•HCl, and it has the next chemical construction.
Treatment method of Overdose Treatment of overdosage is pushed by the general clinical presentation, and consists of discontinuation of Promethazine HCl and Codeine Phosphate Oral Answer along with institution of suitable therapy. Give Principal consideration for the reestablishment of sufficient respiratory exchange by Promethazine codeine syrup means of provision of the patent and guarded airway plus the institution of assisted or controlled air flow.
Posted studies with codeine have noted inconsistent conclusions and possess vital methodological constraints (see Information). There are studies of respiratory melancholy when codeine is made use of throughout labor and supply (see Medical Concerns).
To help protect against withdrawal, your health practitioner could lower your dose slowly but surely. Withdrawal is more likely Should you have utilized this medication for years (more than a few months) or in substantial doses. Inform your health care provider or pharmacist instantly When you have withdrawal.